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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Cannabinoid receptor 2
Species	Homo sapiens (Human)
Gene	CNR2
Synonym	Peripheral cannabinoid receptor rCB2 hCB2 cannabinoid receptor 2 (macrophage) cannabinoid receptor 2 (spleen) CB-2 CB2 CB2 receptor CB2-R CX5 [ Show all ]
Disease	Immune disorder Inflammatory bowel disease Inflammatory disease Neuropathic pain Osteoporosis Pain Atopic dermatitis Rheumatoid arthritis [ Show all ]
Length	360
Amino acid sequence	MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProt	P34972
Protein Data Bank	5zty
GPCR-HGmod model	P34972
3D structure model	This structure is from PDB ID 5zty.
BioLiP	BL0438927
Therapeutic Target Database	T37693
ChEMBL	CHEMBL253
IUPHAR	57
DrugBank	BE0000095

Ligand

Name	CHEMBL2163571
Molecular formula	C28H35N3O3
IUPAC name	N-(1-adamantyl)-2-ethyl-10-oxo-6-pyrrolidin-1-yl-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5,7,9(13),11-tetraene-11-carboxamide
Molecular weight	461.606
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.2
Synonyms	N-(1-Adamantyl)-3-ethyl-10-pyrrolizino-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzooxazine-6-carboxamide BDBM50395150 J3.566.426B
Inchi Key	AQFXWTYTJAHYTB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H35N3O3/c1-2-20-16-34-26-23(30-7-3-4-8-30)6-5-21-24(26)31(20)15-22(25(21)32)27(33)29-28-12-17-9-18(13-28)11-19(10-17)14-28/h5-6,15,17-20H,2-4,7-14,16H2,1H3,(H,29,33)
PubChem CID	60196094
ChEMBL	CHEMBL2163571
IUPHAR	N/A
BindingDB	50395150
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	29.0 nM	PMID22738271	BindingDB,ChEMBL
Ki	8.12 nM	PMID22738271	BindingDB,ChEMBL

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