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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Rattus norvegicus (Rat)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	436
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP
UniProt	P31388
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3372
IUPHAR	11
DrugBank	N/A

Ligand

Name	Bufotenium
Molecular formula	C13H19N2O+
IUPAC name	2-(5-hydroxy-1H-indol-3-yl)ethyl-trimethylazanium
Molecular weight	219.308
Hydrogen bond acceptor	1
Hydrogen bond donor	2
XlogP	1.2
Synonyms	AC1LCVFT CHEMBL317971 2-(5-hydroxy-1H-indol-3-yl)ethyl-trimethylazanium Bufoteninium PDSP1_001578 CHEBI:31879 1H-Indole-3-ethanaminium, 5-hydroxy-N,N,N-trimethyl- B3361[2-(5-Hydroxy-1H-indol-3-yl)-ethyl]-trimethyl-ammonium DTXSID90209469 5-HTQ PDSP2_001562 60657-23-0 2-(5-hydroxy-1H-indol-3-yl)ethyl-trimethyl-ammonium BDBM50130280 N,N,N-Trimethylserotonin 5-Hydroxy-N,N,N-trimethyl-1H-indole-3-ethanaminium C13664 [ Show all ]
Inchi Key	HIYGARYIJIZXGW-UHFFFAOYSA-O
Inchi ID	InChI=1S/C13H18N2O/c1-15(2,3)7-6-10-9-14-13-5-4-11(16)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3/p+1
PubChem CID	656705
ChEMBL	CHEMBL317971
IUPHAR	N/A
BindingDB	50130280
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID9225298	BindingDB

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