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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Adenosine receptor A1
Species	Rattus norvegicus (Rat)
Gene	Adora1
Synonym	A1 receptor A1-AR A1R adenosine receptor A1 RDC7
Disease	N/A for non-human GPCRs
Length	326
Amino acid sequence	MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
UniProt	P25099
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL318
IUPHAR	18
DrugBank	N/A

Ligand

Name	CHEMBL307307
Molecular formula	C14H15N5
IUPAC name	1-methyl-4-pyrrolidin-1-yl-[1,2,4]triazolo[4,3-a]quinoxaline
Molecular weight	253.309
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	2.9
Synonyms	BAS 13125159 MCULE-8123194462 1-Methyl-4-pyrrolidin-1-yl-[1,2,4]triazolo[4,3-a]quinoxaline CCG-161848 SR-01000101415-1 AC1MH66B ChemDiv3_012253 BDBM50015819 MolPort-002-026-093 4-(1-Pyrrolidinyl)-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline ZINC4414789 AKOS000425099 HMS1507M21 BRD-K61693233-001-01-0 SR-01000101415 [ Show all ]
Inchi Key	ABSOKPVCKVXBCK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H15N5/c1-10-16-17-14-13(18-8-4-5-9-18)15-11-6-2-3-7-12(11)19(10)14/h2-3,6-7H,4-5,8-9H2,1H3
PubChem CID	2996934
ChEMBL	CHEMBL307307
IUPHAR	N/A
BindingDB	50015819
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	49000.0 nM	PMID2374150	BindingDB,ChEMBL

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