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GPCR

NameMu-type opioid receptor
SpeciesMus musculus (Mouse)
GeneOprm1
Synonymopioid receptor, mu 1
opioid receptor
OP3
Mu receptor
MOR-1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length398
Amino acid sequenceMDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProtP42866
Protein Data Bank4dkl, 5c1m, 6dde, 6ddf
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 4dkl.
BioLiPBL0416752, BL0416751, BL0321492, BL0224753, BL0224754, BL0224755,BL0224756, BL0321491
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2858
IUPHAR319
DrugBankN/A

Ligand

NameCHEMBL2442636
Molecular formulaC15H19NOS
IUPAC name(2E,4E,6E)-N-(2-methylpropyl)-7-thiophen-2-ylhepta-2,4,6-trienamide
Molecular weight261.383
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.0
Synonyms(2E,4E,6E)-N-Isobutyl-7-(2-thienyl)-2,4,6-heptatrienamide
Inchi KeyHGIRIKHYYMPDAG-IZMYCKBJSA-N
Inchi IDInChI=1S/C15H19NOS/c1-13(2)12-16-15(17)10-6-4-3-5-8-14-9-7-11-18-14/h3-11,13H,12H2,1-2H3,(H,16,17)/b4-3+,8-5+,10-6+
PubChem CID73349612
ChEMBLCHEMBL2442636
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki52000.0 nMPMID24095014ChEMBL

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