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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	CHEMBL338081
Molecular formula	C22H26N2O
IUPAC name	5-methyl-2-(3-phenylmethoxypropyl)-3,4-dihydro-1H-pyrido[4,3-b]indole
Molecular weight	334.463
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.6
Synonyms	BDBM50132103 2-(3-Benzyloxy-propyl)-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
Inchi Key	HEBDLMZEGPOGHC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26N2O/c1-23-21-11-6-5-10-19(21)20-16-24(14-12-22(20)23)13-7-15-25-17-18-8-3-2-4-9-18/h2-6,8-11H,7,12-17H2,1H3
PubChem CID	44351171
ChEMBL	CHEMBL338081
IUPHAR	N/A
BindingDB	50132103
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	650.0 nM	PMID12930153	BindingDB,ChEMBL

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