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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameCID 44292665
Molecular formulaC153H224N44O47S
IUPAC name(3R)-4-[[(2R)-1-[[(2S)-1-[[(2R,5S,8R,11S,14R,17S,20R,23S,26S,34R)-26-[[(2S)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-4-amino-1-[[(2R,3S)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]-23-(3-amino-3-oxopropyl)-8-(carboxymethyl)-14,17-bis[3-(diaminomethylideneamino)propyl]-11-(hydroxymethyl)-2-[(4-hydroxyphenyl)methyl]-20-methyl-5-(2-methylpropyl)-3,6,9,12,15,18,21,24,28,35-decaoxo-1,4,7,10,13,16,19,22,25,29-decazacyclopentatriacont-34-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-[[(2R)-2-[[(2R,3S)-2-[[(2R)-2-[[(2R,3S)-2-[[2-[[(2R)-5-amino-2-[[(2R)-2-[[(2R)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-4-oxobutanoic acid
Molecular weight3463.8
Hydrogen bond acceptor52
Hydrogen bond donor52
XlogP-14.5
SynonymsN/A
Inchi KeyGZVSROXIFXKJFP-NSAVLJCCSA-N
Inchi IDInChI=1S/C153H224N44O47S/c1-72(2)52-97(134(227)177-96(47-51-245-11)133(226)185-104(60-115(158)210)144(237)196-121(76(8)202)124(159)217)180-138(231)103(58-83-64-168-89-29-19-18-28-87(83)89)184-132(225)95(43-46-114(157)209)178-149(242)120(74(5)6)195-142(235)101(54-79-24-14-12-15-25-79)183-139(232)105-61-116(211)165-48-21-20-30-90(130(223)181-99(56-81-33-37-85(205)38-34-81)136(229)179-98(53-73(3)4)135(228)187-107(63-119(215)216)141(234)192-110(69-200)147(240)175-92(32-23-50-167-153(162)163)129(222)173-91(31-22-49-166-152(160)161)128(221)171-75(7)125(218)172-94(131(224)186-105)42-45-113(156)208)174-146(239)109(68-199)191-137(230)100(57-82-35-39-86(206)40-36-82)182-140(233)106(62-118(213)214)188-148(241)111(70-201)193-151(244)123(78(10)204)197-143(236)102(55-80-26-16-13-17-27-80)189-150(243)122(77(9)203)194-117(212)66-169-127(220)93(41-44-112(155)207)176-145(238)108(67-198)190-126(219)88(154)59-84-65-164-71-170-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,168,198-206H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,207)(H2,156,208)(H2,157,209)(H2,158,210)(H2,159,217)(H,164,170)(H,165,211)(H,169,220)(H,171,221)(H,172,218)(H,173,222)(H,174,239)(H,175,240)(H,176,238)(H,177,227)(H,178,242)(H,179,229)(H,180,231)(H,181,223)(H,182,233)(H,183,232)(H,184,225)(H,185,226)(H,186,224)(H,187,228)(H,188,241)(H,189,243)(H,190,219)(H,191,230)(H,192,234)(H,193,244)(H,194,212)(H,195,235)(H,196,237)(H,197,236)(H,213,214)(H,215,216)(H4,160,161,166)(H4,162,163,167)/t75-,76+,77+,78+,88-,90-,91+,92-,93-,94+,95-,96-,97-,98+,99-,100-,101+,102-,103-,104-,105+,106-,107-,108-,109+,110+,111-,120-,121-,122-,123-/m1/s1
PubChem CID44292665
ChEMBLCHEMBL266411
IUPHARN/A
BindingDB50087844
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50794.0 nMPMID10794689BindingDB,ChEMBL
IC50190.0 nMPMID10794689BindingDB,ChEMBL

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