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GLASS

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GPCR

Name	Relaxin receptor 1
Species	Homo sapiens (Human)
Gene	RXFP1
Synonym	Relaxin family peptide receptor 1 RX1 relaxin/insulin like family peptide receptor 1 relaxin receptor 1 RXFPR1 LGR7 leucine-rich repeat-containing G-protein-coupled receptor 7 Leucine-rich repeat-containing G-protein coupled receptor 7 RXFP1 [ Show all ]
Disease	Acute heart failure
Length	757
Amino acid sequence	MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
UniProt	Q9HBX9
Protein Data Bank	2jm4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2jm4.
BioLiP	BL0101296
Therapeutic Target Database	T73696
ChEMBL	CHEMBL1293316
IUPHAR	351
DrugBank	N/A

Ligand

Name	AC1ORZTA
Molecular formula	C15H18N4O5S
IUPAC name	N-[4-[(1,3-dimethyl-2,6-dioxopyrimidin-4-yl)methylsulfamoyl]phenyl]acetamide
Molecular weight	366.392
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	-1.0
Synonyms	N-(4-(N-((1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl)sulfamoyl)phenyl)acetamide CHEMBL1494013 SMR000652123 MLS001158499 AKOS005542522 N-(4-{[(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]sulfamoyl}phenyl)acetamide HMS2958G06 STK606630 904265-13-0 MolPort-002-662-853 N-[4-[(1,3-dimethyl-2,6-dioxopyrimidin-4-yl)methylsulfamoyl]phenyl]acetamide MCULE-6577851205 ZINC5488967 [ Show all ]
Inchi Key	APGGNUNZWQEHQW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H18N4O5S/c1-10(20)17-11-4-6-13(7-5-11)25(23,24)16-9-12-8-14(21)19(3)15(22)18(12)2/h4-8,16H,9H2,1-3H3,(H,17,20)
PubChem CID	7711621
ChEMBL	CHEMBL1494013
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	21862.1 nM	PubChem BioAssay data set	ChEMBL
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL
Potency	43620.6 nM	PubChem BioAssay data set	ChEMBL

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