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GPCR

Name	Metabotropic glutamate receptor 2
Species	Homo sapiens (Human)
Gene	GRM2
Synonym	mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor
Disease	Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder Psychiatric disorder Schizophrenia Alzheimer disease; Major depressive disorder [ Show all ]
Length	872
Amino acid sequence	MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	Q14416
Protein Data Bank	5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 5cnj.
BioLiP	BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443
Therapeutic Target Database	T62820
ChEMBL	CHEMBL5137
IUPHAR	290
DrugBank	N/A

Ligand

Name	(2S,1'S,2'S)-2-(carboxycyclopropyl)glycine
Molecular formula	C6H9NO4
IUPAC name	(1S,2S)-2-[(S)-amino(carboxy)methyl]cyclopropane-1-carboxylic acid
Molecular weight	159.141
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.4
Synonyms	Tox21_500374 L-2-(Carboxypropyl)glycine NCGC00024541-02 B6264 D0Z7CZ L-CCG-l NCGC00024541-05 SR-01000075799 (1S,2S)-2-[(1S)-1-amino-2-hydroxy-2-oxoethyl]cyclopropane-1-carboxylic acid 2S,1'S,2'S)-2-(Carboxycyclopropyl)Glycine CCG-204469 HMS3261K09 LP00374 ZINC2568218 (2S,3S,4S)-CCG AC1NSJQB CHEMBL280563 L-CCG-1 NCGC00024541-03 NCGC00261059-01 (1S,2S)-2-((S)-Amino(carboxy)methyl)cyclopropanecarboxylic acid 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid BDBM50034504 EU-0100374 L-CCGI SR-01000075799-1 (2S,1 inverted exclamation markaS,2 inverted exclamation markaS)-2-(Carboxycyclopropyl)glycine 3,4-Cyclopropylglutamate CCPG J-003677 MolPort-003-940-678 117857-93-9 AKOS006275493 Cyclopropaneacetic acid, alpha-amino-2-carboxy-, (alphaS,1S,2S)- L-Ccg-I NCGC00024541-04 SCHEMBL664330 (1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanecarboxylic acid 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid(2S,3S,4S-CCG) C-237 GTPL1368 Lopac0_000374 [ Show all ]
Inchi Key	GZOVEPYOCJWRFC-HZLVTQRSSA-N
Inchi ID	InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
PubChem CID	5310956
ChEMBL	CHEMBL280563
IUPHAR	1368
BindingDB	50034504
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	300.0 nM	PMID12166935	ChEMBL
EC50	300.0 nM	PMID14711315	BindingDB
EC50	380.0 nM	PMID7738999	BindingDB,ChEMBL
EC50	750.0 nM	PMID7738999	BindingDB
Ki	300.0 nM	PMID9131252	BindingDB
Ki	490.0 nM	PMID8863838, PMID10893301	BindingDB,ChEMBL
Ki	501.187 nM	PMID10530814	IUPHAR

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