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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Trhr
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	N/A for non-human GPCRs
Length	412
Amino acid sequence	MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASEKNGPSSCTYGYSLTAKQEKI
UniProt	Q01717
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4553
IUPHAR	363
DrugBank	N/A

Ligand

Name	CHEMBL191346
Molecular formula	C22H31N6O5+
IUPAC name	1-[6-(2-carbamoylpyrrolidin-1-yl)-6-oxo-5-[(5-oxopyrrolidine-2-carbonyl)amino]hexyl]pyridin-1-ium-3-carboxamide
Molecular weight	459.527
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	-2.0
Synonyms	1-[5-(5-Oxo-2-pyrrolidinylcarbonylamino)-6-oxo-6-[2-(aminocarbonyl)pyrrolizino]hexyl]-3-(aminocarbonyl)pyridinium BDBM50156183 3-carbamoyl-1-{6-(2-carbamoyl-pyrrolidin-1-yl)-6-oxo-5-[(5-oxo-pyrrolidine-2-carbonyl)-amino]-hexyl}-pyridinium;
Inchi Key	GZHUROBPKHYTPP-UHFFFAOYSA-O
Inchi ID	InChI=1S/C22H30N6O5/c23-19(30)14-5-3-11-27(13-14)10-2-1-6-16(26-21(32)15-8-9-18(29)25-15)22(33)28-12-4-7-17(28)20(24)31/h3,5,11,13,15-17H,1-2,4,6-10,12H2,(H5-,23,24,25,26,29,30,31,32)/p+1
PubChem CID	44398398
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50156183
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID15537357	BindingDB

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