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GPCR

NameHistamine H3 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh3
SynonymGPCR97
H3 receptor
H3R
HH3R
DiseaseN/A for non-human GPCRs
Length445
Amino acid sequenceMERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProtQ9QYN8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4124
IUPHAR264
DrugBankN/A

Ligand

NameSCHEMBL7976815
Molecular formulaC10H16N2O
IUPAC name5-[3-(cyclopropylmethoxy)propyl]-1H-imidazole
Molecular weight180.251
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP1.3
SynonymsCHEMBL1179649
AOSGVBLCIFHNSQ-UHFFFAOYSA-N
Cyclopropylmethyl 3-(1H-imidazol-4-yl)propyl ether
4-(3-Cyclopropylmethoxy-propyl)-1H-imidazole; compound with (Z)-but-2-enedioic acid
BDBM50146142
Inchi KeyAOSGVBLCIFHNSQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H16N2O/c1(2-10-6-11-8-12-10)5-13-7-9-3-4-9/h6,8-9H,1-5,7H2,(H,11,12)
PubChem CID11480814
ChEMBLN/A
IUPHARN/A
BindingDB50146142
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki167.0 nMPMID15115409BindingDB

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