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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Trace amine-associated receptor 1
Species	Mus musculus (Mouse)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHAITNISHRNSDWSREVQASLYSLMSLIILATLVGNLIVIISISHFKQLHTPTNWLLHSMAIVDFLLGCLIMPCSMVRTVERCWYFGEILCKVHTSTDIMLSSASIFHLAFISIDRYCAVCDPLRYKAKINISTILVMILVSWSLPAVYAFGMIFLELNLKGVEELYRSQVSDLGGCSPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRTNVQVGLEGKSQAPQSKETKAAKTLGIMVGVFLVCWCPFFLCTVLDPFLGYVIPPSLNDALYWFGYLNSALNPMVYAFFYPWFRRALKMVLLGKIFQKDSSRSKLFL
UniProt	Q923Y8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4908
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL3641726
Molecular formula	C14H16N4O
IUPAC name	N-[4-[(2R)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight	256.309
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.3
Synonyms	US8802673, 176 BDBM129534 SCHEMBL12610024
Inchi Key	GRTXXEQLBRFGLV-ZDUSSCGKSA-N
Inchi ID	InChI=1S/C14H16N4O/c1-6-16-14(17-7-1)18-12-4-2-11(3-5-12)13-10-15-8-9-19-13/h1-7,13,15H,8-10H2,(H,16,17,18)/t13-/m0/s1
PubChem CID	68325733
ChEMBL	CHEMBL3641726
IUPHAR	N/A
BindingDB	129534
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	151.6 nM	, None	BindingDB,ChEMBL

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