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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

NameUNII-UGT5535REQ
Molecular formulaC17H18ClNO
IUPAC name(5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol
Molecular weight287.787
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.0
SynonymsCCG-204548
NCGC00024877-02
Sch 23388
UGT5535REQ
87075-17-0
[ Show all ]
Inchi KeyGOTMKOSCLKVOGG-OAHLLOKOSA-N
Inchi IDInChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
PubChem CID3036864
ChEMBLCHEMBL62
IUPHARN/A
BindingDB82247
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<10000.0 nMPMID1971308, PMID2405158BindingDB,ChEMBL
IC50600.0 nMPMID3172140BindingDB,ChEMBL
IC501900.0 nMPMID3172140BindingDB,ChEMBL
Inhibition53.0 %PMID3039136ChEMBL
K0.5<500.0 nMPMID7636869ChEMBL
K0.5600.0 nMPMID8568818ChEMBL
Ki<1000.0 nMPMID8863801BindingDB,ChEMBL
Ki0.537 nMPMID10425088ChEMBL
Ki359.0 nMPMID2905002BindingDB
Ki569.0 nMPMID11044891BindingDB
Ki600.0 nMPMID2966245BindingDB,ChEMBL
Ki648.0 nMPMID2666667BindingDB
Ki648.0 nMPMID2666667ChEMBL
Ki676.08 nMPMID7996543ChEMBL
Ki760.0 nM, PMID6387355, Bioorg. Med. Chem. Lett., (1992) 2:5:399BindingDB,ChEMBL
Ki820.0 nMPMID2136916BindingDB,ChEMBL
Ki886.0 nMPMID1833546BindingDB,ChEMBL
Ki895.0 nMPMID2415793, PMID1397049, PMID7855175BindingDB
Ki900.0 nMPMID3050089, PMID1397049BindingDB,ChEMBL
Ki2367.0 nMPMID1356154BindingDB
Ki2500.0 nMPMID2532362BindingDB
Ki3300.0 nMPMID2532362BindingDB
Ki4650.0 nMPMID8278895BindingDB
Ki5000.0 nMPMID12023552BindingDB
Ki5560.0 nMPMID1356154BindingDB

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