Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 8iod Chain R

Receptor sequence >8iodR (length=270) Species: 9606,392809 [Search protein sequence] GIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVS MSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAI AVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYV ILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGATSMQGAVTVTM LLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDP LIYAFRSQEMRKTFKEIICC

3D structure PDB 8iod Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Chain R Resolution 2.59 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number ?

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 peptide R I96 V111 D115 D119 I122 I178 S181 I187 L190 F254 M261 F277 L281 I60 V75 D79 D83 I86 I142 S145 I151 L154 F212 M219 F235 L239 BS02 CA R E92 D115 D119 E56 D79 D83

Gene Ontology Molecular Function GO:0004930 G protein-coupled receptor activity GO:0004977 melanocortin receptor activity GO:0005515 protein binding GO:0042562 hormone binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0019222	regulation of metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component