BioLiP

Structure of PDB 8aox Chain PA

Receptor sequence

>8aoxPA (length=432) Species: 371094 (Chikungunya virus strain S27-African prototype) [Search protein sequence]

PVYVDIDADSAFLKALQRAYPMFEVEPRQVTPNDHANARAFSHLAIKLIE
QEIDPDSTILDIGSAPARRMMSDRKYHCVCPMRSAEDPERLANYARKLAS
AAGKVLDRNISGKIGDLQAVMAVPDTETPTFCLHTDVSCRQRADVAIYQD
VYAVHAPTSLYHQAIKGVRLAYWVGFDTTPFMYNAMAGAYPSYSTNWADE
QVLKAKNIGLCSTDLTEGRRGKLSIMRGKKLEPCDRVLFSVGSTLYPESR
KLLKSWHLPSVFHLKGKLSTCRCDTVVSCEGYVVKRITMSPGLYGKTTGY
AVTHHADGFLMCKTTDTVDGERVSFSVCTYVPATICDQMTGILATEVTPE
DAQKLLVGLNQNTMKNYMIPVVAQAFSKWAKECRKDMEDEKLLGVRERTL
TCCCLWAFKKQKTHTVYKRPDTQSIQKVQAEF

3D structure

PDB

8aox Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-
2.7.7.-
2.7.7.19: polynucleotide adenylyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
3.1.3.84: ADP-ribose 1''-phosphate phosphatase.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.1.74: mRNA 5'-phosphatase.
3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	PA	H79 E129 C134 C141	H77 E127 C132 C139
BS02	SAM	PA	G65 P83 S86 D89 R92 T137 D138 Q151 D152	G63 P81 S84 D87 R90 T135 D136 Q149 D150

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0008174	mRNA methyltransferase activity

	Biological Process
GO:0006396	RNA processing
GO:0016556	mRNA modification

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:8aox, PDBe:8aox, PDBj:8aox
PDBsum	8aox
PubMed	36913573
UniProt	Q8JUX6\|POLN_CHIKS Polyprotein P1234