Structure of PDB 1xls Chain G

Receptor sequence

>1xlsG (length=242) Species: 10090 (Mus musculus) [Search protein sequence]

NQQQKELVQILLGAHTRHVGPLFDQFVQFRPPAYLFMHHRPFQPRGPVLP
LLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISL
NTTFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQE
PEYVLMAATALFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSR
FLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS

3D structure

PDB

1xls The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.

Chain

Resolution

2.96 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	G	I183 K184 K187 R193 M197 I201 K205 L352 E355	I67 K68 K71 R77 M81 I85 K89 L236 E239
BS02	TCD	G	N175 F227 Y234 F244 F248 I252 Y336 E339 L346 L353	N59 F111 Y118 F128 F132 I136 Y220 E223 L230 L237

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1xls, PDBe:1xls, PDBj:1xls
PDBsum	1xls
PubMed	15610733
UniProt	O35627\|NR1I3_MOUSE Nuclear receptor subfamily 1 group I member 3 (Gene Name=Nr1i3)

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