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Structure of PDB 1w0c Chain F

Receptor sequence >1w0cF (length=270) Species: 5664 (Leishmania major) [Search protein sequence] TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNAR RPNSAITVQADLSNVATAPSAPVTLFTRCAELVAACYTHWGRCDVLVNNA SSFYPTPLLRNDGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAK HRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIR VNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSK AKYITGTCVKVDGGYSLTRA

3D structure PDB 1w0c Inhibition of Leishmania Major Pteridine Reductase by 2,4,6-Triaminoquinazoline: Structure of the Nadph Ternary Complex Chain F Resolution 2.6 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) R17 D181 Y194 Catalytic site (residue number reindexed from 1) R13 D163 Y176 Enzyme Commision number 1.5.1.33: pteridine reductase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 NAP F G13 R17 L18 H36 Y37 H38 R39 S40 L66 N109 A110 S111 S112 M179 V180 D181 K198 P224 G225 L226 S227 G9 R13 L14 H32 Y33 H34 R35 S36 L62 N99 A100 S101 S102 M161 V162 D163 K180 P206 G207 L208 S209 BS02 TAQ F S111 F113 Y194 S101 F103 Y176 BindingDB: Kd=58750nM

Gene Ontology Molecular Function GO:0004155 6,7-dihydropteridine reductase activity GO:0016491 oxidoreductase activity GO:0047040 pteridine reductase activity

	Biological Process
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0031427	response to methotrexate

	Cellular Component
GO:0005829	cytosol

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