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Structure of PDB 6b5e Chain E

Receptor sequence >6b5eE (length=286) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQ LITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGAD SVALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFGAE GMALSLEEKPVTPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVN QVYLNQGRLAVEVLARGTAWLDTGTFDSLLDAADFVRTLERRQGLKVSIP EEVAWRMGWIDDEQLVQRARALVKSGYGNYLLELLE

3D structure PDB 6b5e The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes. Chain E Resolution 1.85 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 2.7.7.24: glucose-1-phosphate thymidylyltransferase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 DAU E L6 G8 Q24 Q80 P83 G85 L86 L106 G107 D108 Y142 G143 E158 K159 V169 W220 D222 L6 G8 Q24 Q80 P83 G85 L86 L106 G107 D108 Y142 G143 E158 K159 V169 W220 D222 BS02 DAU E M43 Y112 G113 G115 G117 T118 S119 V247 E252 V253 R256 M43 Y112 G113 G115 G117 T118 S119 V247 E252 V253 R256 BS03 MG E D108 D222 D108 D222

Gene Ontology Molecular Function GO:0000287 magnesium ion binding GO:0008879 glucose-1-phosphate thymidylyltransferase activity GO:0016779 nucleotidyltransferase activity GO:0046872 metal ion binding

	Biological Process
GO:0006006	glucose metabolic process
GO:0009058	biosynthetic process
GO:0019305	dTDP-rhamnose biosynthetic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0046075	dTTP metabolic process

	Cellular Component
GO:0005886	plasma membrane
GO:0009274	peptidoglycan-based cell wall

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