Structure of PDB 3prk Chain E

Receptor sequence

>3prkE (length=279) Species: 37998 (Parengyodontium album) [Search protein sequence]

AAQTNAPWGLARISSTSPGTSTYYYDESAGQGSCVYVIDTGIEASHPEFE
GRAQMVKTYYYSSRDGNGHGTHCAGTVGSRTYGVAKKTQLFGVKVLDDNG
SGQYSTIIAGMDFVASDKNNRNCPKGVVASLSLGGGYSSSVNSAAARLQS
SGVMVAVAAGNNNADARNYSPASEPSVCTVGASDRYDRRSSFSNYGSVLD
IFGPGTSILSTWIGGSTRSISGTSMATPHVAGLAAYLMTLGKTTAASACR
YIADTANKGDLSNIPFGTVNLLAYNNYQA

3D structure

PDB

3prk Inhibition of proteinase K by methoxysuccinyl-Ala-Ala-Pro-Ala-chloromethyl ketone. An x-ray study at 2.2-A resolution.

Chain

Resolution

2.2 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	S224
Catalytic site (residue number reindexed from 1)	S224
Enzyme Commision number	3.4.21.64: peptidase K.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	E	H69 L96 G100 G102 Y104 S132 L133 G134 N161 S224	H69 L96 G100 G102 Y104 S132 L133 G134 N161 S224
BS02	CA	E	H69 P175 V177 D200 S224	H69 P175 V177 D200 S224

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:3prk, PDBe:3prk, PDBj:3prk
PDBsum	3prk
PubMed	1894649
UniProt	P06873\|PRTK_PARAQ Proteinase K (Gene Name=PROK)

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