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Structure of PDB 9ezj Chain D

Receptor sequence >9ezjD (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] LIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWE LDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALD FNDFREYLFQSLQFRLLENKIGVLEENELLLKSEQEKTLLELVEAWLERT PGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKE VLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLT SLMDIDSLMTKWRYNHVCMVHRMLGRYKVFVDLFNLSTYLIPRHWIPKMN PTIHKFLYTAEY

3D structure PDB 9ezj Discovery and binding mode of small molecule inhibitors of the apo form of human TDO2 Chain D Resolution 2.612 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 1.13.11.11: tryptophan 2,3-dioxygenase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 ZIQ D R103 E105 W208 R211 T212 P213 F304 R64 E66 W146 R149 T150 P151 F242 BS02 A1H8G D F72 H76 F129 F140 F153 Q154 S155 H328 L336 F33 H37 F90 F101 F109 Q110 S111 H266 L274

Gene Ontology Molecular Function GO:0004833 tryptophan 2,3-dioxygenase activity GO:0005515 protein binding GO:0016597 amino acid binding GO:0019825 oxygen binding GO:0020037 heme binding GO:0042802 identical protein binding GO:0046872 metal ion binding GO:0051213 dioxygenase activity

	Biological Process
GO:0006568	tryptophan metabolic process
GO:0006569	tryptophan catabolic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019442	tryptophan catabolic process to acetyl-CoA
GO:0051289	protein homotetramerization
GO:1904842	response to nitroglycerin

	Cellular Component
GO:0005829	cytosol

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