Structure of PDB 6w8j Chain D

Receptor sequence

>6w8jD (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]

AEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRH
QGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNP
VMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKF
SKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDV
SNMSHLARQRLLGRSWSVPVIRHLFAPLKEYFACV

3D structure

PDB

6w8j Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.

Chain

Resolution

2.445 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	S708 C710 N711 V716 N717 E756 V758 R792 R831 T832 T834 T835 R836 G890 R891	S81 C83 N84 V89 N90 E129 V131 R165 R204 T205 T207 T208 R209 G263 R264
BS02	dna	D	V716 P718 R720 V763 S881	V89 P91 R93 V136 S254
BS03	SAH	D	F640 D641 G642 I643 T645 E664 V665 D686 V687 G707 R891 S892 W893	F13 D14 G15 I16 T18 E37 V38 D59 V60 G80 R264 S265 W266

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity

View graph for
Molecular Function

External links

PDB	RCSB:6w8j, PDBe:6w8j, PDBj:6w8j
PDBsum	6w8j
PubMed	32385248
UniProt	Q9Y6K1\|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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