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Structure of PDB 6ueg Chain D

Receptor sequence >6uegD (length=257) Species: 381754 (Pseudomonas aeruginosa PA7) [Search protein sequence] SLIDPRAIIDPSARLAADVQVGPWSIVGAEVEIGEGTVIGPHVVLKGPTK IGKHNRIYQFSSVGEDTPDLKYKGEPTRLVIGDHNVIREGVTIHRGTVQD RAETTIGDHNLIMAYAHIGHDSVIGNHCILVNNTALAGHVHVDDWAILSG YTLVHQYCRIGAHSFSGMGSAIGKDVPAYVTVFGNPAEARSMNFEGMRRR GFSSEAIHALRRAYKVVYRQGHTVEEALAELAESAAQFPEVAVFRDSIQS ATRGITR

3D structure PDB 6ueg Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography. Chain D Resolution 2.0 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) H121 D122 G139 Catalytic site (residue number reindexed from 1) H120 D121 G138 Enzyme Commision number 2.3.1.129: acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 Q5G D H118 A138 H156 Q157 H117 A137 H155 Q156 MOAD: Kd=19.5uM BS02 Q5G D V132 N133 M169 V131 N132 M168 MOAD: Kd=19.5uM

Gene Ontology Molecular Function GO:0008780 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity GO:0016740 transferase activity GO:0016746 acyltransferase activity

	Biological Process
GO:0008610	lipid biosynthetic process
GO:0009245	lipid A biosynthetic process

	Cellular Component
GO:0005737	cytoplasm

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