BioLiP

Structure of PDB 8xfv Chain C

Receptor sequence

>8xfvC (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]

VPLIGSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFL
EATLRSLTAGWHVELDPFTASTPLGPVDFGNVVATLDPRAARHLTLACHY
DSKLFPPGSTPFVGATDSAVPCALLLELAQALDLELSRAKKQAAPVTLQL
LFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLD
LLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGE
PFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLC
RILAVFLAEYLGL

3D structure

PDB

8xfv X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.

Chain

Resolution

3.13 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.2.5: glutaminyl-peptide cyclotransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	C	D186 E226 H351	D117 E157 H282
BS02	A1D46	C	D186 E225 E230 W231 D269 H351	D117 E156 E161 W162 D200 H282

External links

PDB	RCSB:8xfv, PDBe:8xfv, PDBj:8xfv
PDBsum	8xfv
PubMed	38817193
UniProt	Q9NXS2\|QPCTL_HUMAN Glutaminyl-peptide cyclotransferase-like protein (Gene Name=QPCTL)

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