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Structure of PDB 6orr Chain C

Receptor sequence >6orrC (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] HHSSGLVPRGSMESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILK HLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQ NLQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVL KCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKP GGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVIS QSYSSTMANNEGLFSLVARKLSR

3D structure PDB 6orr High-Affinity Alkynyl Bisubstrate Inhibitors of NicotinamideN-Methyltransferase (NNMT). Chain C Resolution 2.25 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 N37 C Y11 Y20 Y25 G63 S64 Y69 D85 Y86 S87 C141 D142 T163 L164 A169 A198 S201 Y204 Y22 Y31 Y36 G74 S75 Y80 D96 Y97 S98 C152 D153 T174 L175 A180 A209 S212 Y215 MOAD: Ki=500pM BindingDB: Ki=500nM

Gene Ontology Molecular Function GO:0008112 nicotinamide N-methyltransferase activity GO:0008168 methyltransferase activity GO:0030760 pyridine N-methyltransferase activity

	Biological Process
GO:0006769	nicotinamide metabolic process
GO:0009410	response to xenobiotic stimulus
GO:0031100	animal organ regeneration
GO:0032259	methylation
GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0045722	positive regulation of gluconeogenesis
GO:0090312	positive regulation of protein deacetylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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