Structure of PDB 5hgv Chain C

Receptor sequence

>5hgvC (length=674) Species: 9606 (Homo sapiens) [Search protein sequence]

AVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA
DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI
PEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD
QLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEH
PKDLKLSDGRLRVGYVSSNFGNHPTSHLMQSIPGMHNPDKFEVFCYALSP
DDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKG
ARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEK
LAYMPHTFFIGDHANMFPHLKKKAVIDFKHIYDNRIVLNGIDLKAFLDSL
PDVKIVKMNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQIN
NKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANI
LKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRR
GQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLG
CLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTM
ELERLYLQMWEHYAAGNKPDHMIK

3D structure

PDB

5hgv How the glycosyltransferase OGT catalyzes amide bond cleavage.

Chain

Resolution

2.05 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	D431 S494 H496 H517 N557 Y632 T633 K634 Q839 V895 P897	D96 S159 H161 H182 N222 Y297 T298 K299 Q485 V541 P543
BS02	UDP	C	Q839 K842 L866 V895 A896 K898 H901 H920 T921 T922 D925	Q485 K488 L512 V541 A542 K544 H547 H566 T567 T568 D571	BindingDB: IC50=1800nM

External links

PDB	RCSB:5hgv, PDBe:5hgv, PDBj:5hgv
PDBsum	5hgv
PubMed	27618188
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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