BioLiP

Structure of PDB 5brm Chain C

Receptor sequence

>5brmC (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]

DLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGT
NIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTI
LKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRREL
APLQELIEKL

3D structure

PDB

5brm Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.

Chain

Resolution

2.651 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	C	E94 Y95 H96 R154 R157 Y163 H164 F167 E176 N180 E200 L207	E43 Y44 H45 R103 R106 Y112 H113 F116 E125 N129 E149 L156
BS02	peptide	C	F65 N66 N69 P133 S134 K135 I136	F14 N15 N18 P82 S83 K84 I85
BS03	ZN	C	C79 C84 H161 H166	C28 C33 H110 H115

External links

PDB	RCSB:5brm, PDBe:5brm, PDBj:5brm
PDBsum	5brm
PubMed	26108669
UniProt	Q9H8S9\|MOB1A_HUMAN MOB kinase activator 1A (Gene Name=MOB1A)

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