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Structure of PDB 4hiz Chain C

Receptor sequence
>4hizC (length=655) Species: 948870 (Escherichia phage phi92) [Search protein sequence]
DGRNLTFKVTTLPDISKFKNAAFVYERIVGQPLTYVSEGFFDGNLTKITD
TPFYNAWTQDKTFVYDNVIYAPFMAGERHGVQNLHVAWVKSGDDGQTWSM
PEWLTPIHPDYTADKVNYHCMSMGVCGNRLYAVIETRYLSNMRLKKAELW
SRPMPYYRRPTGGITISSGSTTATIVLKKHGLKVGDAVNFSNSGATGVSG
NMTVASVINKDTFTVTLARAATSNIDNTGTTWHFGTRFWDSPWEITELPD
VAYSTNADLCVTETHSFTVIDDDNYTFAVGYHNGDISPRRLGILYFNNAY
SDPSSFTRRTISQEYADNAAEPCIKYYDGILYLTTRGTSTSAAGSTLAMS
ADLGENWNYLRFPNNVHHTNLPFAKVGDYLYIFGTERSFGEWEGQELDNR
YKGTYPRTFMCKINVSSWPVSLSNVQWFNITDQIYQGHIVNSACGVGSVC
VKDGWLYYIFGGEDFLSPWSIGDNSKKLWYKHDGHPADLYSYRLKITEHD
FVSRDFKYGATPNRTLPVSMGTDGVRHVSAPVTFDNDVQMYSLTVTGLEH
DGTQQSAVRVKLDGDYGVIAKNIPIKNPSEQRLILCGGETPYTTDGSLLQ
LYGSNHTYPNRAILYAPGGAYTQNNFMPYLDGQVSLGGASNRWSEVYAST
GTINT
3D structure
PDB4hiz Crystal Structure of Endosialidase from Phage phi92 that cleaves alpha2,8- and alpha2,9-linked polysialic acid
ChainC
Resolution1.601 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y155 H180 E422 R437 R488
Catalytic site (residue number reindexed from 1) Y54 H79 E321 R336 R387
Enzyme Commision number 3.2.1.129: endo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SLB C G298 S300 G197 S199
BS02 SIA C S292 N293 S300 S191 N192 S199
BS03 FRU C Y219 E249 I346 Y118 E148 I245
BS04 CA C T152 P153 F154 H586 A588 D589 T51 P52 F53 H485 A487 D488
Gene Ontology
Molecular Function
GO:0016996 endo-alpha-(2,8)-sialidase activity

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Molecular Function
External links

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