BioLiP

Structure of PDB 2i14 Chain C

Receptor sequence

>2i14C (length=389) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]

MKRFYIANEDEIKAGKTTDVYFLRTKKILEVKNIRKKVLADVTTTSLPNN
WRWGVLVGVEEVAKLLEGIPVNVYAMPEGTIFHPYEPVLQIEGDYADFGI
YETALLGMLSQASGIATAALRIKIAAKFKPVYSFGIRHMHPAIAPMIDRA
AFIGGCDGVSGVLGAEMMGEKAVGTMPHALIITVGDQVKAWKYFDEVIEE
EVPRIALVDTFYDEKVEAVMAAEALGKKLFAVRLDTPSSRRGNFRKIIEE
VRWELKVRGYDWVKIFVSGGLDEEKIKEIVDVVDAFGVGGAIASAKPVDF
ALDIVEVEGKPIAKRGKLSGRKQVYRCENGHYHVVPANKKLERCPVCNAK
VEPLLKPIIENGEIVVEFPKAREIREYVLEQAKKFNLEI

3D structure

PDB

2i14 Crystal structure of nicotinate-nucleotide pyrophosphorylase from Pyrococcus furiosus

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.3.4.21: nicotinate phosphoribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	C	C1327 H1331 C1344 C1347	C327 H331 C344 C347
BS02	ZN	C	H1178 D1209 D1235	H178 D209 D235
BS03	PCP	C	F1134 R1137 H1138 P1177 H1178 R1233 D1235 G1270 G1289 G1290	F134 R137 H138 P177 H178 R233 D235 G270 G289 G290

Gene Ontology

	Molecular Function
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0004516	nicotinate phosphoribosyltransferase activity
GO:0016740	transferase activity
GO:0016763	pentosyltransferase activity
GO:0016874	ligase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009435	NAD biosynthetic process
GO:0019363	pyridine nucleotide biosynthetic process

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Molecular Function

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Biological Process

PDB	RCSB:2i14, PDBe:2i14, PDBj:2i14
PDBsum	2i14
PubMed
UniProt	Q8TZS9