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Structure of PDB 2a2z Chain C

Receptor sequence >2a2zC (length=222) Species: 9606 (Homo sapiens) [Search protein sequence] RIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTNVLQM MYEKPERWSFTFQTYACLSRIRAQLASLNGKEKPVLFFERSVYSDRYIFA SNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHR IYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDV NEDFKDKYESLVEKVKEFLSTL

3D structure PDB 2a2z Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization. Chain C Resolution 3.02 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) E53 R128 Catalytic site (residue number reindexed from 1) E34 R90 Enzyme Commision number 2.7.1.113: deoxyguanosine kinase. 2.7.1.74: deoxycytidine kinase. 2.7.1.76: deoxyadenosine kinase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 MG C S35 E127 S16 E89 BS02 DCZ C I30 E53 W58 Y86 F96 Q97 D133 F137 E197 I11 E34 W39 Y52 F62 Q63 D95 F99 E159 BS03 UDP C A31 A32 G33 K34 S35 T36 R188 R192 D241 F242 A12 A13 G14 K15 S16 T17 R150 R154 D203 F204

Gene Ontology Molecular Function GO:0004136 deoxyadenosine kinase activity GO:0004137 deoxycytidine kinase activity GO:0004138 deoxyguanosine kinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016301 kinase activity GO:0019136 deoxynucleoside kinase activity GO:0042803 protein homodimerization activity GO:0043771 cytidine kinase activity

	Biological Process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006220	pyrimidine nucleotide metabolic process
GO:0009224	CMP biosynthetic process
GO:0016310	phosphorylation
GO:0106383	dAMP salvage
GO:1901135	carbohydrate derivative metabolic process
GO:1901293	nucleoside phosphate biosynthetic process

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

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