Structure of PDB 1wc1 Chain C

Receptor sequence

>1wc1C (length=192) Species: 118562 (Arthrospira platensis) [Search protein sequence]

LRPEPRLITILFSDIVGFTRMSNALQSQGVAELLNEYLGEMTRAVFENQG
TVDKFVGDAIMALYGAPEEMSPSEQVRRAIATARQMLVALEKLNQGWQER
GLVGVPPVRFRCGIHQGMAVVGLFGSQERSDFTAIGPSVNIAARLQEATA
PNSIMVSAMVAQYVPDEEIIKREFLELKGIDEPVMTCVINPN

3D structure

PDB

1wc1 Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment

Chain

Resolution

1.93 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.13.3: histidine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TAT	C	P1197 N1198	P191 N192	MOAD: Ki~0.1mM
BS02	TAT	C	K1057 M1064 V1145 N1146 A1149 R1150	K54 M61 V139 N140 A143 R144	MOAD: Ki~0.1mM
BS03	TAT	C	D1017 G1020 F1021 T1022 G1060 D1061	D14 G17 F18 T19 G57 D58	MOAD: Ki~0.1mM
BS04	MG	C	D1017 D1061	D14 D58
BS05	MG	C	D1017 I1018 D1061	D14 I15 D58

Gene Ontology

	Biological Process
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction

View graph for
Biological Process

External links

PDB	RCSB:1wc1, PDBe:1wc1, PDBj:1wc1
PDBsum	1wc1
PubMed	15619637
UniProt	O32393

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