Structure of PDB 7suv Chain B

Receptor sequence

>7suvB (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]

ALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDIL
CLQQTKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQAPLKV
SYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAF
RKFLKGLASRKPLVLCGNLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGE
LLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLL
PALCDSKIRSKALGSDHCPITLYLAL

3D structure

PDB

7suv Processing oxidatively damaged bases at DNA strand breaks by APE1.

Chain

Resolution

1.99 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

3.1.11.2: exodeoxyribonuclease III.
3.1.21.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	N222 N226 M271 K276 W280	N180 N184 M229 K234 W238
BS02	dna	B	Y128 Y171 N174 R177 N212 F266 T268 L282	Y86 Y129 N132 R135 N170 F224 T226 L240
BS03	dna	B	G71 R73 A74 K78 G127 R177 Y269 M270	G29 R31 A32 K36 G85 R135 Y227 M228

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:7suv, PDBe:7suv, PDBj:7suv
PDBsum	7suv
PubMed	36018803
UniProt	P27695\|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

[Back to BioLiP]

zhanglab

zhanggroup.org | +65-6601-1241 | Computing 1, 13 Computing Drive, Singapore 117417