Structure of PDB 6u67 Chain B

Receptor sequence

>6u67B (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]

AEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDG
VQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLIS
FGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFF
HV

3D structure

PDB

6u67 Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.

Chain

Resolution

1.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Q01	B	M231 L235	M62 L66	MOAD: Ki=0.95uM BindingDB: Ki=950nM
BS02	Q01	B	L235 V253 F254 R263 T266 L267	L66 V84 F85 R94 T97 L98	MOAD: Ki=0.95uM BindingDB: Ki=950nM
BS03	Q01	B	V216 G219 V220 N223 H224 G262 T266	V47 G50 V51 N54 H55 G93 T97	MOAD: Ki=0.95uM BindingDB: Ki=950nM
BS04	BNL	B	V258 R263 T266	V89 R94 T97

Gene Ontology

	Biological Process
GO:0042981	regulation of apoptotic process

View graph for
Biological Process

External links

PDB	RCSB:6u67, PDBe:6u67, PDBj:6u67
PDBsum	6u67
PubMed	31971799
UniProt	Q07820\|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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