BioLiP

Structure of PDB 6qcj Chain B

Receptor sequence

>6qcjB (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]

KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDF
RGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQN
VDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGR
LCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRP
SGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGL
EIPAWDGPRVLERALPPLPRPPTPKLE

3D structure

PDB

6qcj Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.

Chain

Resolution

2.01 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	P62 D63 F64 R65 N114 D116 H133
Catalytic site (residue number reindexed from 1)	P48 D49 F50 R51 N100 D102 H119
Enzyme Commision number	2.3.1.- 2.3.1.286: protein acetyllysine N-acetyltransferase. 2.4.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AR6	B	A53 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258	A39 G40 T43 D49 F50 R51 Q99 H119 G193 T194 S195 I198 N219 L220 Q221 Y236 V237
BS02	ZN	B	C141 C144 C166 C177	C127 C130 C152 C156
BS03	XEG	B	I61 P62 F64 F86 M136 G155 T156 M157	I47 P48 F50 F72 M122 G141 T142 M143

Gene Ontology

	Molecular Function
GO:0070403	NAD+ binding

View graph for
Molecular Function

PDB	RCSB:6qcj, PDBe:6qcj, PDBj:6qcj
PDBsum	6qcj
PubMed	31844103
UniProt	Q8N6T7\|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)