BioLiP

Structure of PDB 4xzr Chain B

Receptor sequence

>4xzrB (length=423) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

AELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLV
EFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGS
VEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTAT
WTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSD
GPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQV
VINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIP
PLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDL
LEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKI
FNCQQNENDKIYEKAYKIIETYF

3D structure

PDB

4xzr Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.

Chain

Resolution

2.25 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	R117 W153 N157 A159 S160 G161 T166 E191 Q192 W195 N199 D203 W237 K246 G287 V327 T328 W363 S366 N367 A370 E402 W405 N409 S412 R443	R31 W67 N71 A73 S74 G75 T80 E105 Q106 W109 N113 D117 W151 K160 G201 V241 T242 W277 S280 N281 A284 E316 W319 N323 S326 R357

External links

PDB	RCSB:4xzr, PDBe:4xzr, PDBj:4xzr
PDBsum	4xzr
PubMed	26051712
UniProt	Q02821\|IMA1_YEAST Importin subunit alpha (Gene Name=SRP1)

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