BioLiP

Structure of PDB 4afy Chain B

Receptor sequence

>4afyB (length=250) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]

HMQRGDVIAILQQALETNSFRLLFQPVISLRGDSHENYEVLLRLLNPQGQ
EVPPAEFLHAAKEAGLAEKIDRWVILNSIKLLAEHRAKGHQTKLFVHLSS
ASLQDPGLLPWLGVALKAARLPPESLVFQISEADATSYLKQAKQLTQGLA
TLHCQAAISQFGCSLNPFNALKHLTVQFIKIDGSFVQDLNQVENQEILKG
LIAELHEQQKLSIVPFVESASVLATLWQAGATYIQGYYLQGPSQAMDYDF

3D structure

PDB

4afy Crystal Structure of an Eal Domain in Complex with Reaction Product 5'-Pgpg

Chain

Resolution

2.01 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.4.52: cyclic-guanylate-specific phosphodiesterase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	B	E492 D685 F686	E56 D249 F250
BS02	rna	B	E475 K498 H533 S535 Q565 D570 S595 Q596 K616 D618 G619 P651 F652 Q671	E39 K62 H97 S99 Q129 D134 S159 Q160 K180 D182 G183 P215 F216 Q235
BS03	MG	B	E475 Q671	E39 Q235

External links

PDB	RCSB:4afy, PDBe:4afy, PDBj:4afy
PDBsum	4afy
PubMed	23285035
UniProt	Q9HUK6

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