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Structure of PDB 3n8h Chain B

Receptor sequence >3n8hB (length=262) Species: 177416 (Francisella tularensis subsp. tularensis SCHU S4) [Search protein sequence] AMIIADNIKQFHSIRNSLIKQQKIGFVPTMGALHNGHISLIKKAKSENDV VIVSIFVNPTQFNNPNDYQTYPNQLQQDIQILASLDVDVLFNPSEKDIYP DGNLLRIEPKLEIANILEGKSRPGHFSGMLTVVLKLLQITKPNNLYLGEK DYQQVMLIKQLVKDFFINTKIIVCPTQRQPSGLPLSSRNKNLTSTDIEIA NKIYEILRQDDFSNLEELTNKINSTGAKLQYIQKLNNRIFLAFYIGKVRL IDNFLKETGPSC

3D structure PDB 3n8h Crystal Structure of Pantoate-beta-alanine Ligase from Francisella tularensis Chain B Resolution 2.001 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) M29 H33 H36 Q76 D77 I80 K149 S185 S186 R187 Catalytic site (residue number reindexed from 1) M30 H34 H37 Q77 D78 I81 K150 S186 S187 R188 Enzyme Commision number 6.3.2.1: pantoate--beta-alanine ligase (AMP-forming).

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 PRO B M29 Q60 R121 H124 D150 Q153 M30 Q61 R122 H125 D151 Q154 BS02 AMP B P27 M29 H33 G35 H36 L39 L146 G147 D150 T175 Q176 L184 P28 M30 H34 G36 H37 L40 L147 G148 D151 T176 Q177 L185

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0004592 pantoate-beta-alanine ligase activity GO:0005524 ATP binding GO:0016874 ligase activity

	Biological Process
GO:0009058	biosynthetic process
GO:0015940	pantothenate biosynthetic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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