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Structure of PDB 2zif Chain B

Receptor sequence >2zifB (length=243) Species: 274 (Thermus thermophilus) [Search protein sequence] VHRLHVGDAREVLASFPEASVHLVVTSPPYWTLGHIEDYEAFLDELDRVW REVFRLLVPGGRLVIVVGDVAVARRRFGRHLVFPLHADIQVRCRKLGFDN LNPIIWHKHTPYEPGAIIKTEIEYILMQRKPGGYRKPTQEQREKSRLPKE DFHRFFRQIWDDIPGEAPFPLELAERLVRMFSFVGDVVLDPFAGTGTTLI AAARWGRRALGVELVPRYAQLAKERFAREVPGFSLEVLDGATH

3D structure PDB 2zif Crystal structure of a putative DNA methylase TTHA0409 from Thermus thermophilus HB8 Chain B Resolution 2.4 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) S47 P48 V96 Catalytic site (residue number reindexed from 1) S27 P28 V66 Enzyme Commision number 2.1.1.- 2.1.1.113: site-specific DNA-methyltransferase (cytosine-N(4)-specific).

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 SAM B D28 A29 S47 P48 P49 P219 F220 F243 A244 G245 T246 T248 E264 L265 D8 A9 S27 P28 P29 P168 F169 F192 A193 G194 T195 T197 E213 L214 MOAD: Kd=43uM

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0015667 site-specific DNA-methyltransferase (cytosine-N4-specific) activity

	Biological Process
GO:0009307	DNA restriction-modification system
GO:0032259	methylation

	Cellular Component
GO:0005737	cytoplasm

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