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Structure of PDB 2qrn Chain B

Receptor sequence >2qrnB (length=228) Species: 9606 (Homo sapiens) [Search protein sequence] RIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSNGGNVL QMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYS DRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATP ETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVP ILTLDVNEDFKDKYESLVEKVKEFLSTL

3D structure PDB 2qrn Structures of human deoxycytidine kinase product complexes. Chain B Resolution 3.4 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) E53 R128 Catalytic site (residue number reindexed from 1) E34 R96 Enzyme Commision number 2.7.1.113: deoxyguanosine kinase. 2.7.1.74: deoxycytidine kinase. 2.7.1.76: deoxyadenosine kinase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 MG B S35 E127 S16 E95 BS02 UDP B A31 G33 K34 S35 T36 R192 D241 F242 A12 G14 K15 S16 T17 R160 D209 F210 BS03 DCM B I30 E53 W58 Y86 R128 F137 E197 I11 E34 W39 Y54 R96 F105 E165

Gene Ontology Molecular Function GO:0004136 deoxyadenosine kinase activity GO:0004137 deoxycytidine kinase activity GO:0004138 deoxyguanosine kinase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016301 kinase activity GO:0019136 deoxynucleoside kinase activity GO:0042803 protein homodimerization activity GO:0043771 cytidine kinase activity

	Biological Process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006220	pyrimidine nucleotide metabolic process
GO:0009224	CMP biosynthetic process
GO:0016310	phosphorylation
GO:0106383	dAMP salvage
GO:1901135	carbohydrate derivative metabolic process
GO:1901293	nucleoside phosphate biosynthetic process

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

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