Structure of PDB 2c2m Chain B

Receptor sequence

>2c2mB (length=103) Species: 9606 (Homo sapiens) [Search protein sequence]

ASGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLK
QYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELY
FYH

3D structure

PDB

2c2m Design, Synthesis, and Evaluation of Aza-Peptide Michael Acceptors as Selective and Potent Inhibitors of Caspases-2, -3, -6, -7, -8, -9, and - 10.

Chain

Resolution

1.94 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.4.22.56: caspase-3.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	Y204 S205 W206 R207 S209 S249 F250 F252	Y30 S31 W32 R33 S35 S75 F76 F78

Gene Ontology

	Molecular Function
GO:0004197	cysteine-type endopeptidase activity
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2c2m, PDBe:2c2m, PDBj:2c2m
PDBsum	2c2m
PubMed	16970398
UniProt	P42574\|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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