Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 1kog Chain B

Receptor sequence >1kogB (length=401) Species: 562 (Escherichia coli) [Search protein sequence] RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQ EVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIF NQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEE QIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADL AVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPS RLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQ VVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVP YMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLE E

3D structure PDB 1kog Structural basis of translational control by Escherichia coli threonyl tRNA synthetase. Chain B Resolution 3.5 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) Q381 D383 K465 Catalytic site (residue number reindexed from 1) Q140 D142 K224 Enzyme Commision number 6.1.1.3: threonine--tRNA ligase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 rna B G344 L345 S347 Y348 R349 V498 E500 N502 G103 L104 S106 Y107 R108 V257 E259 N261 PDBbind-CN: Kd=0.01uM BS02 rna B K249 I547 T548 D549 N575 K577 F580 I582 R583 R609 K8 I306 T307 D308 N334 K336 F339 I341 R342 R368 PDBbind-CN: Kd=0.01uM BS03 ZN B C334 H385 H511 C93 H144 H270 BS04 TSB B M332 R363 E365 V376 F379 Q381 D383 H385 Y462 Q479 C480 T482 Q484 H511 R512 G516 S517 R520 M91 R122 E124 V135 F138 Q140 D142 H144 Y221 Q238 C239 T241 Q243 H270 R271 G275 S276 R279

Gene Ontology Molecular Function GO:0000166 nucleotide binding GO:0004812 aminoacyl-tRNA ligase activity GO:0004829 threonine-tRNA ligase activity GO:0005524 ATP binding

	Biological Process
GO:0006418	tRNA aminoacylation for protein translation
GO:0006435	threonyl-tRNA aminoacylation

	Cellular Component
GO:0005737	cytoplasm

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component