BioLiP

Structure of PDB 9grq Chain A

Receptor sequence

>9grqA (length=300) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]

SSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQL
CQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDL
NDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFF
TYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNAS
SSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKF
PLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNNEN

3D structure

PDB

9grq Crystal structures of SARS-CoV-2 methyltransferase nsp10-16 with Cap0-site binders

Chain

Resolution

1.85 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TEP	A	C6823 D6824 L6825 Y6828 K6935	C25 D26 L27 Y30 K137
BS02	SAM	A	N6841 Y6845 G6869 G6871 P6878 G6879 D6897 L6898 C6913 D6928 M6929 Y6930	N43 Y47 G71 G73 P80 G81 D99 L100 C115 D130 M131 Y132

External links

PDB	RCSB:9grq, PDBe:9grq, PDBj:9grq
PDBsum	9grq
PubMed
UniProt	P0DTD1\|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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