BioLiP

Structure of PDB 8yla Chain A

Receptor sequence

>8ylaA (length=328) Species: 331117 (Aspergillus fischeri NRRL 181) [Search protein sequence]

MEVWEHSRPIADDTIKKTPSFTTLPIRINKQNDVADAATRRALRDWDYYL
HDGLAERALISISELGNLGAFAYPEVPPERLAIVTYLTDLGILHDDGYEA
MDMDQARTEHREFGALFDPHEQLPSRRGTRAAKLKKLVSQILLEAIRIDR
DMGMYMFDMYNKGWLSVAGGEGKVPQFKSVEEYQAYRRDDFGIRAFWPMV
EFGMAMRLSDEDKKLIEPVMEPIDKAIIWTNDYWSFDREYHESITNGSRL
TNVVEVVRQIENKSIDEAKAAVRQLLVNLEQQYLERKRAIYAQNPSIPSH
LRKWIEVVGITVAGTHFWASCSPRHHAW

3D structure

PDB

8yla Structural Insights into the Terpene Cyclization Domains of Two Fungal Sesterterpene Synthases and Enzymatic Engineering for Sesterterpene Diversification.

Chain

Resolution

1.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.29: geranylgeranyl diphosphate synthase.
2.5.1.81: geranylfarnesyl diphosphate synthase.
4.2.3.176: sesterfisherol synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	A	D95 E99	D95 E99
BS02	MG	A	N231 S235 E239	N231 S235 E239
BS03	PPV	A	R187 N231 S235 R238 E239 R324	R187 N231 S235 R238 E239 R324
BS04	BTM	A	W164 F191 M199	W164 F191 M199

External links

PDB	RCSB:8yla, PDBe:8yla, PDBj:8yla
PDBsum	8yla
PubMed	38584136
UniProt	A1DN30\|NFSS_NEOFI Sesterfisherol synthase (Gene Name=NfSS)

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