BioLiP

Structure of PDB 8xgk Chain A

Receptor sequence

>8xgkA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]

PKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVG
GLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVI
DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL
LYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYA
AGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG
YDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP

3D structure

PDB

8xgk Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors.

Chain

Resolution

1.32 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1LVB	A	R415 G462 R483 S508 G509 Y525 S555 A556 Y572 F577 S602 G603	R94 G141 R162 S187 G188 Y204 S234 A235 Y251 F256 S281 G282

External links

PDB	RCSB:8xgk, PDBe:8xgk, PDBj:8xgk
PDBsum	8xgk
PubMed	38408347
UniProt	Q14145\|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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