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BioLiP

Structure of PDB 8xcw Chain A

Receptor sequence
>8xcwA (length=416) Species: 49899 (Thermococcus profundus) [Search protein sequence]
IDPFEMAVKQLERAAQYMDISEEALEWLKKPMRIVEVSVPIEMDDGSVKV
FTGFRVQHNWARGPTKGGIRWHPAETLSTVKALATWMTWKVAVVDLPYGG
GKGGIIVNPKELSEREQERLARAYIRAVYDVIGPWTDIPAPDVYTNPKIM
GWMMDEYETIMRRKGPAFGVITGKPLSIGGSLGRGTATAQGAIFTIREAA
KALGIDLKGKKIAVQGYGNAGYYTAKLAKEQLGMTVVAVSDSRGGIYNPD
GLDPDEVLKWKREHGSVKDFPGATNITNEELLELEVDVLAPAAIEEVITE
KNADNIKAKIVAEVANGPVTPEADDILREKGILQIPDFLCNAGGVTVSYF
EWVQNINGYYWTEEEVREKLDKKMTKAFWEVYNTHKDKNIHMRDAAYVVA
VSRVYQAMKDRGWVKK
3D structure
PDB8xcw CryoEM-sampling of metastable conformations appearing in cofactor-ligand association and catalysis of glutamate dehydrogenase
ChainA
Resolution2.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.1.3: glutamate dehydrogenase [NAD(P)(+)].
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A T191 Y220 G221 A223 D244 S245 K264 N281 A296 A318 N319 N344 T188 Y217 G218 A220 D241 S242 K261 N278 A293 A315 N316 N341
BS02 AKG A K69 M90 K93 A143 K66 M87 K90 A140
Gene Ontology
Molecular Function
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0004354 glutamate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Biological Process
GO:0006520 amino acid metabolic process
GO:0006538 glutamate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8xcw, PDBe:8xcw, PDBj:8xcw
PDBsum8xcw
PubMed38750092
UniProtO74024|DHE3_THEPR Glutamate dehydrogenase (Gene Name=gdhA)

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