BioLiP

Structure of PDB 7ju5 Chain A

Receptor sequence

>7ju5A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]

GPLSLSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGR
AGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGP
LLLIVEYAKYGSLRGFLRESRKVGERALTMGDLISFAWQISQGMQYLAEM
KLVHRDLAARNILVAEGRKMKISDFGLSRDVYSQGRIPVKWMAIESLFDH
IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC
SEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRR

3D structure

PDB

7ju5 Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations.

Chain

Resolution

1.9 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D874 A876 R878 N879 D892
Catalytic site (residue number reindexed from 1)	D156 A158 R160 N161 D174
Enzyme Commision number	2.7.10.1: receptor protein-tyrosine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Q4J	A	L730 G731 E732 G733 G736 K737 V738 A756 M759 E805 Y806 A807 G810 L881	L31 G32 E33 G34 G37 K38 V39 A57 M60 E106 Y107 A108 G111 L163	BindingDB: IC50=6000nM

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

PDB	RCSB:7ju5, PDBe:7ju5, PDBj:7ju5
PDBsum	7ju5
PubMed	33161056
UniProt	P07949\|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)