Structure of PDB 6bux Chain A

Receptor sequence

>6buxA (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]

RHSMDPATFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLAQRRGFLA
NQAKHKHGFLEGRHAALCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQ
EMAKFISKNKHVSLCIKTARIYDDKGRAAEGLRTLAEAGAKISIMTYSEF
KHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQE

3D structure

PDB

6bux Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.

Chain

Resolution

1.856 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.5.4.38: single-stranded DNA cytosine deaminase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	W211 R213 H216 T218 N244 A246 K247 H257 W285 S286 Y315 D316 D317 K318	W18 R20 H23 T25 N51 A53 K54 H64 W92 S93 Y122 D123 D124 K125	PDBbind-CN: Kd=55uM
BS02	ZN	A	H257 C288 C291	H64 C95 C98

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity

View graph for
Molecular Function

External links

PDB	RCSB:6bux, PDBe:6bux, PDBj:6bux
PDBsum	6bux
PubMed	29941968
UniProt	Q9HC16\|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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