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Structure of PDB 6afk Chain A

Receptor sequence >6afkA (length=237) Species: 208963 (Pseudomonas aeruginosa UCBPP-PA14) [Search protein sequence] QSMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQ TVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQ AGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAM VLVDAVTRLLPGALDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWR LQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD

3D structure PDB 6afk Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors. Chain A Resolution 2.75 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) P94 E121 R159 Catalytic site (residue number reindexed from 1) P93 E120 R158 Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 SAM A Y91 L92 S93 P94 Q95 G118 Y120 E121 V142 L143 G145 G146 P149 Y90 L91 S92 P93 Q94 G117 Y119 E120 V141 L142 G144 G145 P148

Gene Ontology Molecular Function GO:0008168 methyltransferase activity GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity

	Biological Process
GO:0002939	tRNA N1-guanine methylation
GO:0006400	tRNA modification
GO:0008033	tRNA processing
GO:0032259	methylation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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