BioLiP

Structure of PDB 5vac Chain A

Receptor sequence

>5vacA (length=215) Species: 3988 (Ricinus communis) [Search protein sequence]

RLLPFVSSEDPAQRLKQMGTLASALTELQMEFSDDLTYSSGMAPRSANQA
RFEEGGMQVLTKEDIETLEQCRAMCKRGDCPPLLVVFDSREGFTVEADGQ
IKDMTFIAEYTGDVDYIRNREHDDCDSMMTLLLAKDPSSSLVICPDKRGN
IARFISGINNHTLDGKKKQNCKCVRYSVNGECRVFLVATRDIAKGERLYY
DYNGYEHEYPTQHFV

3D structure

PDB

5vac Molecular basis for the methylation specificity of ATXR5 for histone H3.

Chain

Resolution

1.949 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.369: [histone H3]-lysine(27) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	M216 Q217 Y269 S286 M287 M288 T289 C332 R334 Y361 G363 Y364 E365 E367 Y368	M57 Q58 Y110 S127 M128 M129 T130 C173 R175 Y202 G204 Y205 E206 E208 Y209
BS02	SAH	A	E250 F252 D285 R312 S315 G316 Y361 Y368 F373 V374	E91 F93 D126 R153 S156 G157 Y202 Y209 F214 V215

External links

PDB	RCSB:5vac, PDBe:5vac, PDBj:5vac
PDBsum	5vac
PubMed	28383693
UniProt	B9RU15\|ATXR5_RICCO Probable Histone-lysine N-methyltransferase ATXR5 (Gene Name=ATXR5)

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