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Structure of PDB 4wrn Chain A

Receptor sequence
>4wrnA (length=693) Species: 9606,83334 [Search protein sequence]
GHHHHHHKTEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKL
EEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPAAAFQDKLYPFT
WDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKG
KSALMFNLQEPYFTWPLIAADGGYAFKYAAGKYDIKDVGVDNAGAKAGLT
FLVDLIKNKHMNADTDYSIAEHAFNHGETAMTINGPWAWSNIDTSAVNYG
VTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAV
NKDKPLGAVALKSYEEELVKDPRVAATMENAQKGEIMPNIPQMSAFWYAV
RTAVINAASGRQTVDAALAAAQTNAAAGTCEECSIDEDCKSNNGRWHCQC
KQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCS
GFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDL
NIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPS
YTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSQATDP
LKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCE
VYLCDTMNEKCKPTCSGTAFASGSVIDQSRVLNLGPITRKGVQ
3D structure
PDB4wrn A structured interdomain linker directs self-polymerization of human uromodulin.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 GLC A E135 Y179 W254 E118 Y162 W237
BS02 GLC A W86 D89 E177 P178 Y179 W364 W69 D72 E160 P161 Y162 W347
BS03 ZN A H20 H24 E302 H3 H7 E285
Gene Ontology
Molecular Function
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

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Molecular Function

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Cellular Component
External links
PDB RCSB:4wrn, PDBe:4wrn, PDBj:4wrn
PDBsum4wrn
PubMed26811476
UniProtP07911|UROM_HUMAN Uromodulin (Gene Name=UMOD);
P0AEY0|MALE_ECO57 Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE)

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