BioLiP

Structure of PDB 4qzi Chain A

Receptor sequence

>4qziA (length=336) Species: 10090 (Mus musculus) [Search protein sequence]

KKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSV
LKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYK
SFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYE
DLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFL
ITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILEAQKCFLILKLDHGRV
GKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYATHERKMMLDN
HALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA

3D structure

PDB

4qzi Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.

Chain

Resolution

2.65 Å

3D
structure

Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Catalytic site (original residue number in PDB)	D343 D345 D434
Catalytic site (residue number reindexed from 1)	D196 D198 D260
Enzyme Commision number	2.7.7.31: DNA nucleotidylexotransferase. 3.1.11.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	G186 S187 A190 C216 G218 D219 K220 V221	G39 S40 A43 C69 G71 D72 K73 V74
BS02	dna	A	L189 R193 R458 H466	L42 R46 R284 H292
BS03	dna	A	F256 G257 G259 K261 T262 M288 H342 D343 D345 F405 R432 D434 G449 W450 R454	F109 G110 G112 K114 T115 M141 H195 D196 D198 F240 R258 D260 G275 W276 R280
BS04	ZN	A	D343 D345 D434	D196 D198 D260
BS05	ZN	A	D473 H475	D299 H301
BS06	MG	A	D343 D345	D196 D198
BS07	DCT	A	G333 R336 G341 H342 D343	G186 R189 G194 H195 D196

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

View graph for
Molecular Function

View graph for
Biological Process

PDB	RCSB:4qzi, PDBe:4qzi, PDBj:4qzi
PDBsum	4qzi
PubMed	25762590
UniProt	P09838\|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)