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Structure of PDB 4lkg Chain A

Receptor sequence >4lkgA (length=316) Species: 11320 (Influenza A virus) [Search protein sequence] DKICLGHHAVSNGTKVNTLTERGVEVVNATETVERTNIPRICSKGKRTVD LGQCGLLGTITGPPQCDQFLEFSADLIIERREGSDVCYPGKFVNEEALRQ ILRESGGIDKEAMGFTYSGIRTNGATSSCRRSGSSFYAEMKWLLSNTDNA AFPQMTKSYKNTRKNPALIVWGIHHSGSTAEQTKLYGSGNKLVTVGSSNY QQSFVPSPGARTQVNGQSGRIDFHWLMLNPNDTVTFSFNGAFIAPDRASF LRGKSMGIQSGVQVDADCEGDCYYSGGTIISNLPFQNIDSRAVGKCPRYV KQRSLLLATGMKNVPE

3D structure PDB 4lkg Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses Chain A Resolution 2.994 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number ?

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 GAL A G216 Q217 G216 Q217 PDBbind-CN: -logKd/Ki=6.80,Kd=0.16uM BS02 SIA A Y88 A125 T126 S127 W142 H174 E181 L185 Q217 Y88 A125 T126 S127 W142 H174 E181 L185 Q217 PDBbind-CN: -logKd/Ki=6.80,Kd=0.16uM

Gene Ontology Molecular Function GO:0046789 host cell surface receptor binding

	Biological Process
GO:0019062	virion attachment to host cell
GO:0019064	fusion of virus membrane with host plasma membrane
GO:0039654	fusion of virus membrane with host endosome membrane
GO:0046718	symbiont entry into host cell
GO:0075512	clathrin-dependent endocytosis of virus by host cell

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0019031	viral envelope
GO:0020002	host cell plasma membrane

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